計画研究佐藤班（A01）の安藤敏夫先生（金沢大学数物科学系）のミオシンＶのAFM解析に関する論文が、Nature電子版に掲載されました。以下にご紹介いたします。また、関連記事が朝日新聞（10/11、第2面）に掲載されております。
新聞記事はこちら■タイトル
Video imaging of walking myosin V by high-speed atomic force microscopy
■著者
Noriyuki Kodera, Daisuke Yamamoto, Ryoki Ishikawa, Toshio Ando
■アブストラクト
The dynamic behaviour of myosin V molecules translocating along actin filaments has been mainly studied by optical microscopy. The processive hand-over-hand movement coupled with hydrolysis of adenosine triphosphate was thereby demonstrated. However, the protein molecules themselves are invisible in the observations and have therefore been visualized by electron microscopy in the stationary states. The concomitant assessment of structure and dynamics has been unfeasible, a situation prevailing throughout biological research. Here we directly visualize myosin V molecules walking along actin tracks, using high-speed atomic force microscopy. The high-resolution movies not only provide corroborative 'visual evidence' for previously speculated or demonstrated molecular behaviours, including lever-arm swing, but also reveal more detailed behaviours of the molecules, leading to a comprehensive understanding of the motor mechanism. Our direct and dynamic high-resolution visualization is a powerful new approach to studying the structure and dynamics of biomolecules in action.
DOI : 10.1038/nature09450